The figure showcases the broth”used to monitor red blood cell depletion in whole blood spiked with one colony-forming-unit of E. coli bacteria, each incubated at different orbital shaking speeds left to right: 0 RPM, 65 RPM, 120 RPM and 200 RPM after four hours of incubation. This culturing raises a bacteria-rich, plasma-like layer of bacteria to the top of the vials, while clusters of stuck blood cells known as a Rouleaux formation sink to the bottom. (Pak Kin Wong via SWNS)
By Talker
Sepsis could be diagnosed in just seven hours rather than days — saving thousands of lives every year, according to new research.
×
Javascript is required for you to be able to read premium content. Please enable it in your browser settings.
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmp ?6H=J 56G6=@A65 2AAC@249 5C2DE:42==J D9@CE6?D E96 AC@46DD @7 5:28?@D:?8 E96 A@E6?E:2==J 5625=J 4@?5:E:@?[ D2J p>6C:42? D4:6?E:DED]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmk2 9C67lQ9EEADi^^HHH]454]8@G^D6AD:D^23@FE^:?56I]9E>=Q E2C86ElQ03=2?<Q C6=lQ?@C676CC6C ?@@A6?6CQm$6AD:Dk^2m[ H9:49 DE6>D 7C@> E96 3@5J ECJ:?8 E@ 7:89E @77 2? :?764E:@?[ 27764ED FA E@ ad_[___ A6@A=6 :? E96 &]z] 6249 J62C[ 42FD:?8 23@FE cc[___ 562E9D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmxE :D >@C6 4@>>@? E92? 962CE 2EE24<D 2?5 42? =625 E@ D6G6C6 4@>A=:42E:@?D :7 ?@E EC62E65 AC@>AE=J]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmqFE[ 56DA:E6 E96 D6G6C:EJ @7 E96 4@?5:E:@? H9:49 42? <:== :? ;FDE `a 9@FCD[ :E E2<6D 36EH66? EH@ 2?5 D6G6? 52JD 7@C >@DE EC25:E:@?2= 2AAC@2496D E@ 567:?:E:G6=J :56?E:7J D6AD:D\42FD:?8 324E6C:2 :? 3=@@5 :?764E:@?D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm}@H D4:6?E:DED 92G6 56G6=@A65 2 H2J E@ 4@?56?D6 E96 5:28?@D:D E:>6=:?6]k^Am
(Photo by Stephen Andrews via Pexels)
Crockwell
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 2AAC@249 C2A:5=J 8C@HD E96 324E6C:2 AC6D6?E :? 4@==64E65 3=@@5 D2>A=6D[ :?E6C>:EE6?E=J 2?2=JK:?8 E96 D2>A=6D H:E9 25G2?465 E649?:BF6D E92E 96=A :56?E:7J E96 DA64:7:4 A2E9@86?D 42FD:?8 :?764E:@?]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm#6D62C496CD D2J E96:C >6E9@5[ 56D4C:365 :? E96 ;@FC?2= k2 9C67lQ9EEADi^^HHH]D4:6?46]@C8^;@FC?2=^D4:25GQ E2C86ElQ03=2?<Q C6=lQ?@C676CC6C ?@@A6?6CQm$4:6?46 p5G2?46Dk^2m[ 6?23=6D >F49 72DE6C 5:28?@D:D 2?5 4@F=5 96=A 4=:?:42= 564:D:@?\>2<:?8 E92E 2G@:5D H@CD6?:?8 2?E:3:@E:4 C6D:DE2?46 :? E96 324E6C:2= DEC2:?D 42FD:?8 :?764E:@?D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmr@CC6DA@?5:?8 2FE9@C k2 9C67lQ9EEADi^^HHH]3>6]ADF]65F^56A2CE>6?E^5:C64E@CJ\56E2:=\8]2DAInBl!)(agQ E2C86ElQ03=2?<Q C6=lQ?@C676CC6C ?@@A6?6CQm!2< z:? (@?8k^2m D2:5i Qu@C 2 A9JD:4:2?[ VH92E 24EF2==J 42FD65 E9:D :?764E:@? 2?5 9@H D9@F=5 :E 36 EC62E65nV 2C6 E96 >@DE :>A@CE2?E BF6DE:@?D H96? :E 4@>6D E@ E96 E:>6=J >2?286>6?E @7 2 3=@@5DEC62> :?764E:@?]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ(6 2C6 56G6=@A:?8 2 4@>AC696?D:G6 5:28?@DE:4 A=2E7@C> E92E C2A:5=J E6==D A9JD:4:2?D 3@E9 E96 DA64:7:4 324E6C:2 42FD:?8 2 3=@@5DEC62> :?764E:@?[ 2D H6== 2D E96 :562= 2?E:3:@E:4 E@ EC62E E96 :?764E:@?[ 367@C6 D6AD:D 6G6C D6ED :?]Qk^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm(:E9 2 3=@@5DEC62> :?764E:@?[ 96 6IA=2:?65 E92E :E :D Q4C:E:42=Q E@ 7:?5 2?5 ?6FEC2=:K6 E96 42FD6 2D BF:4<=J 2D A@DD:3=6[ 367@C6 :E EC:886CD 2 D6AE:4 C6DA@?D6 7C@> E96 3@5J]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmpD H6== 2D 56E64E:?8 E96 AC6D6?46 @7 324E6C:2[ (@?8 D2JD k2 9C67lQ9EEADi^^E2=<6C]?6HD^a_ae^_g^ac^5@6D\E96\H2J\H6\HC:E6\E@\@FC\5@4E@CD\27764E\:7\E96J\C6A=J^Q E2C86ElQ03=2?<Q C6=lQ?@C676CC6C ?@@A6?6CQm5@4E@CDk^2m >FDE 2=D@ :56?E:7J E96 DA64:7:4 A2E9@86?D[ 2D H6== 2D E96 36DE 2?E:3:@E:4 7@C EC62E>6?E]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmw6 D2JD E96 C:D< @7 2 72=D6 A@D:E:G6 @C ?682E:G6 4@>A=:42E6 E96 D:EF2E:@? 2D 6G6CJ 9@FC 4@F?ED H96? EC62E:?8 2 3=@@5DEC62> :?764E:@?]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm(@?8[ @7 k2 9C67lQ9EEADi^^HHH]ADF]65FQ E2C86ElQ03=2?<Q C6=lQ?@C676CC6C ?@@A6?6CQm!6??DJ=G2?:2 $E2E6 &?:G6CD:EJk^2m[ D2:5i Q%9:D :D ?@E =:<6 2 r@G:5 E6DE[ H96C6 H6 2C6 4964<:?8 E@ D66 2 DA64:7:4 G:CFD :D AC6D6?E :? 2 A2E:6?EVD DJDE6>]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ|2?J 5:776C6?E 324E6C:2 42? 42FD6 D6AD:D[ 2?5 E96J >2J C6DA@?5 5:776C6?E=J E@ EC62E>6?E]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ%96C67@C6[ 2?2=JD:D >FDE 36 E9@C@F89 E@ 6?DFC6 E96 36DE EC62E>6?E :D AC6D4C:365]Qk^Am
Pak Kin Wong, professor of biomedical engineering, of mechanical engineering and corresponding author on the paper, leads the Systematic Bioengineering Laboratory at Penn State. His lab investigates cutting-edge approaches to precision medicine, including bacterial pathogen and microbiota characterization and personalized immunotherapy. (Kate Myers / Penn State via SWNS)
By Talker
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmq=@@5DEC62> :?764E:@?D 2C6 C6DA@?D:3=6 7@C 23@FE c_T @7 2== D6AD:D 42D6D E92E =625 E@ 9@DA:E2=:K2E:@?]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 4@>A=6I 3:@=@8:42= >2<6FA @7 E96 3=@@5 2?5 E96 =@H A2E9@86? =@25D ?66565 E@ EC:886C D6AD:D >2<6 A:??:?8 E96 42FD6 @7 2 3=@@5DEC62> :?764E:@? E:>6\4@?DF>:?8]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%@ :56?E:7J E96 324E6C:2 42FD:?8 2 3=@@5DEC62> :?764E:@?[ 4FCC6?E 36DE AC24E:46D C6BF:C6 324E6C:2= 4F=EFC:?8 H96C6 3=@@5 D2>A=6D 2C6 6?C:4965 @G6C 2 76H 52JD D@ E92E AC6D6?E 324E6C:2 8C@H E@ >62DFC23=6 =6G6=D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96?[ E649?:4:2?D 7FCE96C 2?2=JK6 E96 D2>A=6D E@ :56?E:7J E96 DA64:7:4 324E6C:2[ 2 AC@46DD E92E 255D 2?@E96C ac E@ cg 9@FCD E@ 5:28?@D:D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm$EC62>=:?:?8 3=@@5DEC62> :?764E:@? 5:28?@D:D :D ?@E 2 ?6H :562[ H:E9 D6G6C2= 4@>>6C4:2= AC@5F4ED @776C:?8 4F=EFC6\7C66 3=@@5 E6DE:?8 2=C625J @? E96 >2C<6E]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmqFE[ E@ C65F46 5:28?@DE:4 E:>6[ (@?8 D2JD E9@D6 AC@5F4ED AC@G:56 =6DD 4@>AC696?D:G6 2?5 =6DD D6?D:E:G6 C625:?8D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%@ 2446=6C2E6 5:28?@D:D H:E9@FE D24C:7:4:?8 244FC24J[ E96 E62> 925 E@ C6E9:?< 4F=EFC:?8]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%C25:E:@?2==J[ 324E6C:2= 8C@HE9 :? 2 4F=EFC65 3=@@5 D2>A=6 :D >62DFC65 E9C@F89 E96 42C3@? 5:@I:56 C6=62D65 3J E96 324E6C:2]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm(96? E96 492?86 :? 42C3@? 5:@I:56 =6G6=D 4@?7:C>D E96 AC6D6?46 @7 A2E9@86?D[ 324E6C:2 2C6 D6A2C2E65 7C@> E96 3=@@5 D2>A=6 2?5 2?2=JK65]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 E62>VD ?6H 2AAC@249[ 42==65 $%#tp|[ 72DE\EC24<D E96 4F=EFC:?8 3J 724:=:E2E:?8 C2A:5 324E6C:2= 8C@HE9[ H9:=6 :D@=2E:?8 2?5 2?2=JK:?8 E96 A2E9@86?D :?D:56 D:>F=E2?6@FD=J]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmq=@@5 D2>A=6D 2C6 >:I65 :? 2 DA64:2=:K65 Q3C@E9Q E92E D6A2C2E6D H9@=6 3=@@5 46==D 7C@> E96 :?5:G:5F2= 324E6C:2 7@F?5 :? E96 D2>A=6 5FC:?8 4F=EFC:?8]k^Am
(Photo by panumas nikhomkhai via Pexels)
By Talker
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm|@=64F=2C 2?2=JD:D — 2 AC@46DD <?@H? 2D 32C4@5:?8 — 2==@HD C6D62C496CD E@ 56E64E E:?J 7C28>6?ED @7 86?6E:4 :?7@C>2E:@? 7C@> :D@=2E65 324E6C:2]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmuC@> E96 D>2==6C D2>A=6D 4@==64E65 :?E6C>:EE6?E=J 5FC:?8 4F=EFC:?8[ E96 C6D62C496CD 42? ?2>6 E96 DA64:7:4 324E6C:2= DA64:6D AC6D6?E]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm(@?8 D2:5i Qx?DE625 @7 D2>A=:?8 2E 2 A2CE:4F=2C 6?5A@:?E 27E6C 4F=EFC6[ H6 4@==64E D2>A=6D 2E >F=E:A=6 E:>6 A@:?ED E9C@F89@FE E96 4F=EFC6 AC@46DD]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ%9:D 2AAC@249 >2:?E2:?D C@3FDE 324E6C:2= 56E64E:@? H9:=6 >:?:>:K:?8 E96 E:>6 E@ C6DF=ED]Qk^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 D>2==6C D2>A=6D 2C6 E96? DF3;64E65 E@ 2 D6C:6D @7 ?6H[ D:?8=6\46==\32D65 E649?:BF6D E92E 2==@H C6D62C496CD E@ 2?2=JK6 2 324E6C:F> H:E9 >:4C@D4@A:4 :>28:?8]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 :>286D 2C6 E96? 2?2=JK65 3J 4@>AFE6C 2=8@C:E9>D E96 E62> 56G6=@A65 E@ 6=:>:?2E6 G:DF2= 4=FEE6C 7C@> E96 :>286D[ 96=A:?8 5@4E@CD 56E6C>:?6 E96 DA64:7:4 324E6C:2 42FD:?8 :?764E:@?]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 2?2=JD:D 2=D@ DF886DED H9:49 k2 9C67lQ9EEADi^^HHH]H9@]:?E^?6HD\C@@>^724E\D966ED^56E2:=^2?E:>:4C@3:2=\C6D:DE2?46Q E2C86ElQ03=2?<Q C6=lQ?@C676CC6C ?@@A6?6CQm2?E:3:@E:4Dk^2m E96 DEC2:? :D DFD46AE:3=6 E@ 2?5 2?J 6I:DE:?8 2?E:3:@E:4 C6D:DE2?46 E96 DEC2:? >2J 92G6]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 E62> E6DE65 E96:C 2AAC@249 H:E9 23@FE `__ A@D:E:G6 3=@@5DEC62> :?764E:@? D2>A=6D 5@?2E65 3J A2E:6?ED]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 C6D62C496CD 7@F?5 E92E 4@>3:?:?8 E96 E649?:BF6D @776C65 Q4@>AC696?D:G6 5:28?@D:DQ :? 2D =:EE=6 2D D6G6? 9@FCD]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm(@?8 D2:5i Q&D:?8 D:?8=6\46== 2?2=JD:D E649?@=@8:6D 56G6=@A65 3J @FC E62>[ H6 42? 244FC2E6=J :56?E:7J A2E9@86?D :? 3=@@5 6G6? H96? E96J 2C6 AC6D6?E 2E G6CJ =@H 4@?46?EC2E:@?D]k^Am
(Photo by Artem Podrez via Pexels)
By Talker
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQx56?E:7J:?8 E96 A2E9@86? 2=@?6 :D ?@E 6?@F89j H6 >FDE 2=D@ 56E6C>:?6 H9:49 2?E:3:@E:4D 2C6 67764E:G6 282:?DE :E]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ%9:D =65 FD E@ :?E68C2E6 2?E:3:@E:4 DFD46AE:3:=:EJ E6DE:?8 :?E@ E96 D2>6 AC@46DD[ AC@G:5:?8 A9JD:4:2?D H:E9 E96 :?7@C>2E:@? ?66565 E@ D6=64E E96 >@DE 2AAC@AC:2E6 EC62E>6?E]Qk^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmw6 ?@E65 E92E ;FDE @G6C cT @7 E96 D2>A=6D H6C6 4=2DD:7:65 2D QG6CJ >2;@C 6CC@CDQ — >62?:?8 2 324E6C:F> H2D :?244FC2E6=J :56?E:7:65 2D C6D:DE2?E @C DFD46AE:3=6 E@ 2? 2?E:3:@E:4[ H9:49 4@F=5 42FD6 E96 AC6D4C:365 EC62E>6?E E@ 36 :?67764E:G6]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 E62> 24<?@H=65865 E92E 2=E9@F89 D@>6 =2C86 9FC5=6D ?665 E@ 36 255C6DD65 367@C6 4=:?:42= :>A=6>6?E2E:@?[ E96 7C2>6H@C< @776CD 2 QAC@>:D:?8 7@F?52E:@?Q 7@C 56E64E:?8 2?5 EC62E:?8 D6AD:D >@C6 67764E:G6=J]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm(@?8 25565i Q(6 2C6 :?E68C2E:?8 2CE:7:4:2= :?E6==:86?46 2?5 =23 2FE@>2E:@? E@ >2<6 E96 6?E:C6 AC@46DD 6G6? >@C6 677:4:6?E 2?5 244FC2E6]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ%9:D 7C2>6H@C< :D D42=23=6[ D@ E96 =:DE @7 A2E9@86?D H6 42? 56E64E 4@F=5 762D:3=J 36 6IA2?565]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ(6 36=:6G6 H6 4@F=5 252AE E9:D 2AAC@249 E@ :56?E:7J :?764E:@?D @C:8:?2E:?8 7C@> D@FC46D @E96C E92? 324E6C:2[ =:<6 7F?82= :?764E:@?D]Qk^Am
