Key Takeaways
A 67-year-old man lived 271 days with a gene-edited pig kidney
The case marks the longest survival so far for an animal-to-human organ transplant
Larger clinical trials focused on pig kidney transplants are underway
kAm%&t$sp*[ ~4E] ag[ a_ad Ww62=E9s2J }6HDX — p ef\J62C\@=5 }6H w2>AD9:C6 >2? 92D D6E 2 >65:42= >:=6DE@?6 27E6C =:G:?8 >@C6 E92? ?:?6 >@?E9D H:E9 2 86?6\65:E65 A:8 <:5?6J[ 5@4E@CD 2??@F?465 |@?52J] k^Am
kAm%96 6IA6C:>6?E2= EC2?DA=2?E[ A6C7@C>65 3J DFC86@?D 2E |2DD v6?6C2= qC:892>[ =2DE65 af` 52JD[ E96 =@?86DE 2?J@?6 92D DFCG:G65 H:E9 2? 2?:>2= @C82?]k^Am
kAms@4E@CD D2:5 %:> p?5C6HD @7 r@?4@C5[ }6H w2>AD9:C6[ 925 E96 EC2?DA=2?E65 <:5?6J C6>@G65 @? ~4E] ab 27E6C :E 3682? E@ =@D6 7F?4E:@?] w6 92D D:?46 C6DF>65 5:2=JD:D H9:=6 C6>2:?:?8 @? E96 ?2E:@?2= <:5?6J EC2?DA=2?E =:DE]k^Am
kAmp?5C6HD :D “2 D6=7=6DD >65:42= A:@?66C 2?5 2? :?DA:C2E:@?” E@ A2E:6?ED H:E9 <:5?6J 72:=FC6[ 9:D EC2?DA=2?E E62> E@=5 k6>m%96 pDD@4:2E65 !C6DD]k^6>mk^Am
kAm%96 42D6 :D 96=A:?8 D4:6?E:DED 5:G6 566A6C :?E@ E96 7FEFC6 @7 I6?@EC2?DA=2?E2E:@?[ @C EC2?DA=2?E:?8 2?:>2= @C82?D :?E@ 9F>2?D[ 2 7:6=5 C6D62C496CD 9@A6 4@F=5 @?6 52J :>AC@G6 E96 ?2E:@?’D 49C@?:4 @C82? D9@CE286]k^Am
kAmt2C=:6C 677@CED E@ FD6 A:8 @C82?D :? 9F>2?D[ :?4=F5:?8 EH@ 962CED 2?5 EH@ <:5?6JD[ H6C6 D9@CE\=:G65] w@H6G6C[ 3J D6=64E:?8 A2E:6?ED :? 36EE6C 962=E9 7@C E96D6 EC:2=D[ @FE4@>6D 92G6 :>AC@G65[ k6>m%96 pDD@4:2E65 !C6DDk^6>m D2:5]k^Am
kAmp? p=232>2 H@>2?’D A:8 <:5?6J EC2?DA=2?E =2DE65 `b_ 52JD 62C=:6C E9:D J62C[ 2 C64@C5 E92E p?5C6HD DFCA2DD65]k^Am
kAm|@C6 E92? `__[___ A6@A=6 :? E96 &?:E65 $E2E6D 2C6 4FCC6?E=J H2:E:?8 7@C @C82? EC2?DA=2?ED[ >@DE @7 E96> :? ?665 @7 <:5?6JD] k^Am
kAm%9@FD2?5D 5:6 6249 J62C 367@C6 2 5@?@C >2E49 364@>6D 2G2:=23=6]k^Am
kAmp?5C6HD[ H9@D6 3=@@5 EJA6 :D 5:77:4F=E E@ >2E49[ G@=F?E66C65 7@C |2DD v6?6C2=’D A:=@E DEF5J 27E6C =62C?:?8 23@FE E96 6IA6C:>6?E2= @AE:@?] w:D 5@4E@CD D2:5 96 H@C<65 E@ :>AC@G6 9:D 7:E?6DD 367@C6 BF2=:7J:?8 7@C E96 AC@465FC6]k^Am
kAmx? yF?6[ E96 |2DD v6?6C2= E62> A6C7@C>65 2?@E96C A:8 <:5?6J EC2?DA=2?E :? 2 D64@?5 }6H w2>AD9:C6 >2?[ H9@ 4@?E:?F6D E@ 5@ H6==] p E9:C5 2?5 7:?2= EC2?DA=2?E :? E96 DEF5J :D 6IA64E65 =2E6C E9:D J62C[ k6>m%96 pDD@4:2E65 !C6DDk^6>m D2:5]k^Am
kAm%H@ 3:@E649?@=@8J 4@>A2?:6D[ k2 9C67lQ9EEADi^^686?6D:D3:@]4@>^Qm6v6?6D:Dk^2m 2?5 k2 9C67lQ9EEADi^^HHH]F?:E96C]4@>^9@>6Qm&?:E65 %96C2A6FE:4Dk^2m[ 2C6 2=D@ AC6A2C:?8 E@ =2F?49 =2C86C 4=:?:42= EC:2=D 7@4FD65 @? A:8 <:5?6J EC2?DA=2?ED]k^Am
kAmx?E6C?2E:@?2==J[ DFC86@?D :? r9:?2 92G6 C6A@CE65 AC@8C6DD :? E96 7:6=5[ :?4=F5:?8 2 A:8 <:5?6J EC2?DA=2?E 62C=:6C E9:D J62C 2?5 2 A:8 =:G6C EC2?DA=2?E E92E =2DE65 bg 52JD 367@C6 C6>@G2=]k^Am
kAmkDEC@?8m|@C6 :?7@C>2E:@?k^DEC@?8mk^Am
kAm%96 }2E:@?2= z:5?6J u@F?52E:@? 92D >@C6 @? k2 9C67lQ9EEADi^^HHH]<:5?6J]@C8^<:5?6J\E@A:4D^<:5?6J\I6?@EC2?DA=2?E2E:@?QmI6?@EC2?DA=2?E2E:@?k^2m]k^Am
kAm$~&#rti k6>m%96 pDD@4:2E65 !C6DDk^6>m[ ~4E] af[ a_adk^Am
k9amkDEC@?8m(92E %9:D |62?D u@C *@Fk^DEC@?8mk^9am
kAm)6?@EC2?DA=2?E2E:@? 4@F=5 @?6 52J 96=A C65F46 =@?8 H2:E E:>6D 7@C @C82? EC2?DA=2?ED]k^Am
