Top 5 diseases affecting men, and the clinical trials racing to treat them
kAmtG6CJ J62C @? u2E96CVD s2J[ H6 46=63C2E6 E96 525D :? @FC =:G6D] qFE p>6C:42? >6? 2C6[ DE2E:DE:42==J[ H@C<:?8 282:?DE E96 @55D] p44@C5:?8 E@ E96 k2 9C67lQ9EEADi^^HHH]454]8@G^?49D^AC@5F4ED^52E23C:67D^53dcg]9E>QmrsrVD }2E:@?2= r6?E6C 7@C w62=E9 $E2E:DE:4Dk^2m[ H@>6? :? E96 &]$] ?@H @FE=:G6 >6? 3J c]h J62CD @? 2G6C286i g`]c J62CD 7@C H@>6? G6CDFD fe]d J62CD 7@C >6? 2D @7 a_ac] p?5 k2 9C67lQ9EEADi^^9DA9]92CG2C5]65F^?6HD^F\D\>6?\5:6\?62C=J\D:I\J62CD\367@C6\H@>6?\2D\=:76\6IA64E2?4J\82A\H:56?D^QmC6D62C49 7C@> w2CG2C5 r92? $49@@= 2?5 &r $2? uC2?4:D4@k^2m DF886DED E96 82A 925 H:56?65 E@ ?62C=J D:I J62CD 2E :ED C646?E A62<]k^Am
kAm!2CE @7 E96 AC@3=6> :D 3:@=@8:42=] qFE A2CE @7 :E :D 3692G:@C2=] k2 9C67lQ9EEADi^^@?=:?6]28:?8]F7=]65F^a_ac^_b^`b^6IA=2:?:?8\E96\=:76\6IA64E2?4J\82A\36EH66?\>6?\2?5\H@>6?^Qmp44@C5:?8 E@ E96 rsrk^2m[ H@>6? 2C6 bbT >@C6 =:<6=J E@ G:D:E E96 5@4E@C E92? >6?[ 2?5 EH:46 2D =:<6=J E@ D66< AC6G6?E:G6 42C6] x? `b @7 E96 `c =625:?8 42FD6D @7 562E9 4@>>@? E@ 3@E9 D6I6D[ k2 9C67lQ9EEADi^^HHH]C82C6]4@>^<?@H=6586\46?E6C^2CE:4=6^:?D:56\E96\=:76\6IA64E2?4J\86?56C\82A\\\2?5\9@H\:?DFC6CD\42?\3F:=5\2\3C:586Qm>6? 92G6 2 9:896C 286\25;FDE65 >@CE2=:EJ C2E6 E92? H@>6?k^2m[ A6C 2 v6@C86E@H? &?:G6CD:EJ DEF5J 4:E65 3J C6:?DFC2?46 7:C> #vp]k^Am
kAm%96 8@@5 ?6HDi #6D62C49 :D 42E49:?8 FA] q6=@H[ k2 9C67lQ9EEADi^^<:G@]:@^Qmz:G@k^2m[ 2 vI!\4@>A=:2?E 5@4F>6?E 2?5 AC@46DD >2?286>6?E A=2E7@C> 7@C =:76 D4:6?46D E62>D[ =@@<D 2E 7:G6 5:D62D6D E92E 5:DAC@A@CE:@?2E6=J 27764E >6? 2?5 E96 4=:?:42= EC:2=D H@C<:?8 E@ 492?86 E96:C AC@8?@D:D]k^Am
k9bm`] !C@DE2E6 r2?46Ck^9bm
kAm!C@DE2E6 42?46C :D E96 >@DE 4@>>@?=J 5:28?@D65 ?@?\D<:? 42?46C :? p>6C:42? >6? 2?5 E96 D64@?5 =625:?8 42FD6 @7 42?46C 562E9[ 369:?5 @?=J =F?8 42?46C] k2 9C67lQ9EEADi^^HHH]42?46C]@C8^42?46C^EJA6D^AC@DE2E6\42?46C^23@FE^<6J\DE2E:DE:4D]9E>=Qmp3@FE ` :? g >6? H:== 36 5:28?@D65 H:E9 AC@DE2E6 42?46C 5FC:?8 E96:C =:76E:>6k^2m[ 244@C5:?8 E@ E96 p>6C:42? r2?46C $@4:6EJ] x? a_ac[ 2? 6DE:>2E65 k2 9C67lQ9EEADi^^AC6DDC@@>]42?46C]@C8^AC@DE2E642?46CC@F?5E23=6Qmahh[_`_ ?6H 42D6D H6C6 5:28?@D65k^2m 2?5 bd[ad_ >6? 5:65 7C@> E96 5:D62D6]k^Am
kAm#24:2= 5:DA2C:E:6D >2<6 E96 A:4EFC6 3=62<6C 7@C D@>6 >6? E92? @E96CD] k2 9C67lQ9EEADi^^AC6DDC@@>]42?46C]@C8^AC@DE2E642?46CC@F?5E23=6Qmq=24< >6? 42CCJ 2 5:DAC@A@CE:@?2E6 3FC56? @7 3@E9 5:28?@D6D 2?5 562E9Dk^2m[ 2 724E E92E AC@>AE65 E96 p>6C:42? r2?46C $@4:6EJ E@ =2F?49 2 565:42E65 }2E:@?2= !C@DE2E6 r2?46C #@F?5E23=6 :? a_ac]k^Am
kAm~? E96 EC:2= 7C@?E[ 2 ?@E23=6 !92D6 b C6DF=E 6>6C865 :? =2E6 a_ac] k2 9C67lQ9EEADi^^:C]42?56=EI]4@>^?6HD\C6=62D6D^?6HD\C6=62D6\56E2:=D^42?56=\E96C2A6FE:4D\2??@F?46D\42?\ac_h\249:6G65\AC:>2CJ\6?5A@:?EQmr2?56= %96C2A6FE:4D 2??@F?465 E92E :ED G:C2= :>>F?@E96C2AJ rp}\ac_h >6E :ED AC:>2CJ 6?5A@:?Ek^2m :? 2 fcd\A2E:6?E EC:2= @7 :?E6C>65:2E6\E@\9:89 C:D< =@42=:K65 AC@DE2E6 42?46C] !2E:6?ED C646:G:?8 rp}\ac_h 2=@?8D:56 DE2?52C5 C25:2E:@? E96C2AJ D2H 2 b_T C65F4E:@? :? E96 C:D< @7 AC@DE2E6 42?46C C64FCC6?46 @C 562E9] %96C6 92D 366? ?@ ?6H EC62E>6?E @C D:8?:7:42?E 492?86 :? E96 DE2?52C5 @7 42C6 7@C =@42=:K65[ ?@?\>6E2DE2E:4 AC@DE2E6 42?46C 7@C @G6C a_ J62CD]k^Am
k9bma] r2C5:@G2D4F=2C s:D62D6k^9bm
kAmw62CE 5:D62D6 :D E96 =625:?8 42FD6 @7 562E9 :? >6? :? E96 &?:E65 $E2E6D[ 244@F?E:?8 7@C C@F89=J ` :? c >2=6 562E9D] p?5 2 k2 9C67lQ9EEADi^^HHH]292;@FC?2=D]@C8^5@:^`_]``e`^ypwp]`ad]_cchaaQm=2?5>2C< a_ae DEF5J AF3=:D965 :? E96 y@FC?2= @7 E96 p>6C:42? w62CE pDD@4:2E:@?k^2m 4@?7:C>D E92E >6? 5@ ?@E D:>A=J 86E 962CE 5:D62D6 >@C6 @7E6? E92? H@>6?i %96J 86E :E D:8?:7:42?E=J 62C=:6C] u@==@H:?8 >@C6 E92? d[___ 25F=ED 7@C @G6C b_ J62CD[ C6D62C496CD 7@F?5 E92E >6? 56G6=@A65 42C5:@G2D4F=2C 5:D62D6 @? 2G6C286 k2 9C67lQ9EEADi^^HHH]4??]4@>^a_ae^_a^_a^962=E9^962CE\5:D62D6\H6==?6DDQmD6G6? J62CD 62C=:6C E92? H@>6?k^2m[ H:E9 C:D< 368:??:?8 E@ 5:G6C86 2D 62C=J 2D 286 bd] r@C@?2CJ 962CE 5:D62D6 5C@G6 E96 82A >@DE 5C2>2E:42==Ji |6? C624965 2 aT C:D< =6G6= 2 7F== `_ J62CD 29625 @7 H@>6?]k^Am
kAm*6E J@F?8 >6? 2C6 E96 56>@8C2A9:4 =62DE =:<6=J E@ 92G6 C68F=2C AC6G6?E:G6 42C6 G:D:ED[ 4C62E:?8 2 H:?5@H @7 >:DD65 @AA@CEF?:EJ AC64:D6=J H96? 62C=J :?E6CG6?E:@? 4@F=5 >2EE6C >@DE]k^Am
kAmr=:?:42= C6D62C49 :D H@C<:?8 E@ 4=@D6 E92E 82A 62C=:6C :? E96 5:D62D6 E:>6=:?6] %96 k2 9C67lQ9EEADi^^=:?<]DAC:?86C]4@>^2CE:4=6^`_]`__f^D``ggb\_ad\_`bfe\IQm't$p{x&$\r' EC:2=k^2m[ AC6D6?E65 2E E96 a_ad p>6C:42? w62CE pDD@4:2E:@? $4:6?E:7:4 $6DD:@?D[ 56>@?DEC2E65 E92E 6G@=@4F>23[ 2 !r$zh :?9:3:E@C[ D:8?:7:42?E=J =@H6C65 7:CDE >2;@C 42C5:@G2D4F=2C 6G6?ED :? 9:89\C:D< 25F=ED H9@ 925 ?@E J6E 6IA6C:6?465 2 962CE 2EE24< @C DEC@<6] |62?H9:=6[ |@F?E $:?2:VD k2 9C67lQ9EEADi^^C6A@CED]>@F?ED:?2:]@C8^2CE:4=6^42C5a_ad\AC6425\42C5:@G2D4F=2C\EC:2=Qm!#trps EC:2=k^2m[ =2F?4965 :? 72== a_ac[ :D E2C86E:?8 J@F?8 25F=ED H:E9 DF34=:?:42= 2E96C@D4=6C@D:D E@ E6DE H96E96C 288C6DD:G6 62C=J C:D< 724E@C 4@?EC@= 42? AC6G6?E 42C5:@G2D4F=2C 6G6?ED =2E6C :? =:76]k^Am
k9bmb] p{$ Wp>J@EC@A9:4 {2E6C2= $4=6C@D:DXk^9bm
kAmp{$ :D k2 9C67lQ9EEADi^^HHH]2=D]@C8^F?56CDE2?5:?8\2=D^H9@\86ED\2=DQma_T >@C6 4@>>@? :? >6? E92? H@>6?k^2m[ 244@C5:?8 E@ E96 p{$ pDD@4:2E:@?[ H:E9 >6? EJA:42==J 56G6=@A:?8 E96 5:D62D6 2E 2 J@F?86C 286] |6? 86E p{$ 2E 2? 2G6C286 @?D6E 286 @7 2C@F?5 e_[ 4@>A2C65 H:E9 eg 7@C H@>6?[ k2 9C67lQ9EEADi^^?6FC@=@8J]5F<6]65F^?6HD^?6FC@=@8J\2?5\>6?D\962=E9\2=D\_QmA6C sF<6 }6FC@=@8Jk^2m] |6? 2C6 >@C6 =:<6=J E@ AC6D6?E H:E9 =:>3\@?D6E p{$[ H9:=6 H@>6? >@C6 4@>>@?=J AC6D6?E H:E9 3F=32C @?D6E]k^Am
kAmp{$ C6>2:?D @?6 @7 >65:4:?6VD >@DE DEF33@C? 492==6?86D] |65:2? DFCG:G2= 27E6C 5:28?@D:D :D EH@ E@ 7:G6 J62CD] ~?=J D:I usp\2AAC@G65 >65:42E:@?D 6I:DE] qFE E96 EC:2= =2?5D42A6 :? a_ac 2?5 a_ad D9@H65 D:8?D @7 2446=6C2E:@?]k^Am
kAmk2 9C67lQ9EEADi^^2=D?6HDE@52J]4@>^?6HD\3J\E@A:4^C6D62C49^Qmp{$ #6D62C49 }6HD C6A@CE65k^2m E92E 27E6C p{$ #U2>Ajs ?@E4965 ag ?6H EC:2= DE2CED :? a_ab[ E96 C2E6 >@C6 E92? 5@F3=65 E@ e_ :? a_ac] ~?6 DE2?5@FE 56G6=@A>6?Ei x? pAC:= a_ac[ 2 A2E:6?E C646:G65 E96 k2 9C67lQ9EEADi^^8=@32=CA9]4@>^a_ad^`_^2=D\?6HD\3C62<E9C@F89\5CF8\D9@HD\AC@>:D:?8\C6DF=ED\:?\4=:?:42=\EC:2=D^Qm7:CDE\6G6C 2?E:D6?D6 @=:8@?F4=6@E:56 EC62E>6?E E2C86E:?8 rwrws`_ >FE2E:@?D :? p{$k^2m[ F?56C E96 $:=6?46 p{$ :?:E:2E:G6[ H:E9 5:D62D6 AC@8C6DD:@? C6A@CE65=J D=@H:?8 3J >@C6 E92? d_T] |62?H9:=6[ k2 9C67lQ9EEADi^^HHH]A92C>2G@:46]4@>^?6HD^2=D\5CF8\>65:4:?@G2\A92C>2\752\A:A6=:?6\=2E6^g_cb`d^Qm|65:4:}@G2 4=@D65 6?C@==>6?Ek^2m :? 2 !92D6 a3^b DEF5J @7 :ED 5F2=\24E:@? D>2== >@=64F=6 |}\`ee[ H9:49 E2C86ED ?6FC@:?7=2>>2E:@? E9C@F89 2 3C@256C >6492?:D> E92? >@DE p{$ 42?5:52E6D] %96 $62? |] w62=6J p{$ !=2E7@C> %C:2= 2E |2DD v6?6C2= qC:892>[ H9:49 92D 6?C@==65 k2 9C67lQ9EEADi^^HHH]>2DD86?6C2=3C:892>]@C8^6?^23@FE^?6HDC@@>^2CE:4=6D^H92ED\E96\=2E6DE\@?\2=D\C6D62C49\2?5\4=:?:42=\EC:2=DQm>@C6 E92? `[b__ A2CE:4:A2?ED 2?5 6G2=F2E65 D6G6? 5CF8Dk^2m[ 92D >@G65 EH@ AC@>:D:?8 42?5:52E6D E@ E96 ?6IE A92D6 @7 E6DE:?8]k^Am
k9bmc] %JA6 a s:236E6Dk^9bm
kAm%JA6 a 5:236E6D :D ?@E 6I4=FD:G6=J 2 5:D62D6 @7 >6?[ 3FE >6? 42CCJ 2 DA64:7:4 2?5 F?56C2AAC64:2E65 5:D25G2?E286i %96J 56G6=@A :E 62C=:6C[ 2?5 2E =@H6C 3@5J H6:89ED[ E92? H@>6?] #6D62C49 AF3=:D965 :? s:236E@=@8:2 4@?7:C>D E92E k2 9C67lQ9EEADi^^=:?<]DAC:?86C]4@>^`_]`__f^D__`ad\_ab\_dgh`\IQmH@C=5H:56[ 2? 6DE:>2E65 `f]f >:==:@? >@C6 >6? E92? H@>6? 92G6 5:236E6Dk^2m[ 2?5 >6? 2C6 EJA:42==J 5:28?@D65 2E 2 J@F?86C 286 2?5 =@H6C 3@5J 72E >2DD] p k2 9C67lQ9EEADi^^AF3>65]?43:]?=>]?:9]8@G^a`hdhhdg^Qm=2C86 DEF5J 7C@> E96 $4@EE:D9 s:236E6D #6D62C49 }6EH@C<k^2m 7@F?5 E92E E96 >62? q|x 2E 5:236E6D 5:28?@D:D :? >6? H2D b`]gb[ 4@>A2C65 E@ bb]eh :? H@>6?[ H:E9 E96 5:776C6?46 >@DE >2C<65 2E J@F?86C 286D] |6?[ :? @E96C H@C5D[ ?665 E@ 82:? =6DD H6:89E E92? H@>6? E@ E:A :?E@ 2 5:236E:4 DE2E6]k^Am
kAm%96 EC62E>6?E =2?5D42A6 7@C %JA6 a 5:236E6D :D @?6 @7 E96 >@DE 24E:G6 :? >65:4:?6] v{!\` C646AE@C 28@?:DED 92G6 5@>:?2E65 C646?E J62CD[ 2?5 E96 A:A6=:?6 36J@?5 E96> :D 566A] %96 k2 9C67lQ9EEADi^^=:?<]DAC:?86C]4@>^2CE:4=6^`_]`__f^D``ggb\_ad\_`bfe\IQmr~#t\%x|x fa2 2?5 r~#ta\%x|x fa3 EC:2=Dk^2m[ AC6D6?E65 2E E96 a_ad pwp $4:6?E:7:4 $6DD:@?D[ D9@H65 E92E @=6K2CD6? >2C<65=J =@H6C65 EC:8=J46C:56D :? A2E:6?ED H:E9 42C5:@>6E23@=:4 5:D62D6[ 2? :>A@CE2?E 4@>A=:42E:@? A2E9H2J :? >6? H:E9 5:236E6D] (:E9 62C=:6C @?D6E 2?5 2 =@?86C 4F>F=2E:G6 6IA@DFC6 E@ 6=6G2E65 3=@@5 DF82C[ >6? H:E9 %JA6 a 5:236E6D 7246 2 =@?86C CF?H2J @7 42C5:@G2D4F=2C 2?5 @C82? 4@>A=:42E:@?Di >@C6 C62D@?[ C6D62C496CD 2C8F6[ 7@C 62C=:6C D4C66?:?8 2?5 62C=:6C EC62E>6?E :?:E:2E:@?]k^Am
k9bmd] %6DE:4F=2C r2?46Ck^9bm
kAm%6DE:4F=2C 42?46C :D E96 >@DE 4@>>@?=J 5:28?@D65 42?46C :? >6? 36EH66? E96 286D @7 `d 2?5 bd[ k2 9C67lQ9EEADi^^HHH]>52?56CD@?]@C8^42?46C\EJA6D^E6DE:4F=2C\42?46C]9E>=Qm244@C5:?8 E@ |s p?56CD@? r2?46C r6?E6Ck^2m] xE :D[ :? C6=2E:G6 E6C>D[ @?6 @7 >65:4:?6VD DF446DD DE@C:6Di %96 7:G6\J62C DFCG:G2= C2E6 :D 2AAC@I:>2E6=J k2 9C67lQ9EEADi^^HHH]>@77:EE]@C8^42?46CD^E6DE:4F=2C\42?46C^72BD^H92E\286\8C@FA\:D\E6DE:4F=2C\42?46C\>@DE\4@>>@?^QmhdT[ 2?5 D@>6 6DE:>2E6D AFE 4FC6 C2E6D 2D 9:89 2D hhTk^2m 7@C =@42=:K65 5:D62D6[ >2<:?8 :E 2>@?8 E96 >@DE EC62E23=6 @7 2== 42?46CD]k^Am
kAmqFE E96 DF446DD @7 EC62E>6?E 4@>6D H:E9 =@?8 D925@HD] k2 9C67lQ9EEADi^^24D;@FC?2=D]@?=:?6=:3C2CJ]H:=6J]4@>^5@:^7F==^`_]bbaa^4224]a`g`hQm#6D62C49 AF3=:D965 :? rpi p r2?46C y@FC?2= 7@C r=:?:4:2?Dk^2m 5@4F>6?E65 6=6G2E65 C:D<D @7 D64@?5 >2=:8?2?4:6D[ :?4=F5:?8 3=2556C[ =6F<6>:2[ 2?5 =F?8 42?46CD[ :? DFCG:G@CD EC62E65 H:E9 A=2E:?F>\32D65 496>@E96C2AJ @C C25:2E:@?] u6CE:=:EJ :D 2=D@ 2 >2;@C 4@?46C?i %96 `d\J62C 72E96C9@@5 C2E6 7@C 2 >2? 2865 b_ 2E 5:28?@D:D H2D D:8?:7:42?E=J =@H6C 7@C E6DE:4F=2C 42?46C A2E:6?ED E92? 286\>2E4965 4@?EC@=D] p4E:G6 4=:?:42= EC:2=D 2C6 7@4FD65 @? C65F4:?8 E96 =@?8\E6C> E@I:4:EJ @7 EC62E>6?E[ :56?E:7J:?8 DFCG6:==2?46 DEC2E68:6D E92E 42? DA2C6 =@H6C\C:D< A2E:6?ED 7C@> F??646DD2CJ 496>@E96C2AJ[ 2?5 F?56CDE2?5:?8 H9J :?4:56?46 C2E6D 92G6 366? DE625:=J 4=:>3:?8 @G6C E96 A2DE 46?EFCJ] $FCG:G@CD9:A[ ?@E ;FDE DFCG:G2=[ :D E96 7C@?E:6C]k^Am
k9bm%96 #6D62C49 xD |@G:?8k^9bm
kAmp4C@DD 2== 7:G6 @7 E96D6 4@?5:E:@?D[ E96 DE@CJ :D E96 D2>6i |6? 2C6 2E 6=6G2E65 C:D<[ 2CC:G6 =2E6 E@ 42C6[ 2?5 92G6 9:DE@C:42==J 366? F?56CD6CG65 3J C6D62C49 E92E 6:E96C 6I4=F565 E96> 7C@> EC:2=D @C D:>A=J 5:5 ?@E AC:@C:E:K6 >2=6\DA64:7:4 5:D62D6 >6492?:D>D] %92E :D 492?8:?8] %96 G@=F>6 @7 EC:2=D[ E96 D@A9:DE:42E:@? @7 E96 D4:6?46[ 2?5 E96 8C@H:?8 4=:?:42= C64@8?:E:@? @7 D6I\32D65 5:776C6?46D :? 5:D62D6 @?D6E 2?5 AC@8C6DD:@? 2== A@:?E E@H2C5 2 >@C6 E2C86E65 7FEFC6 7@C >6?VD 962=E9 C6D62C49]k^Am
kAm%9:D u2E96CVD s2J[ E96 36DE 8:7E 7@C 2 72E96C >:89E 36 E96 D:>A=6DE @?6i 2 4@?G6CD2E:@? 23@FE 86EE:?8 4964<65]k^Am
kAmk2 9C67lQ9EEADi^^<:G@]:@^?6HD^E96\E@A\d\5:D62D6D\27764E:?8\>6?\2?5\E96\4=:?:42=\EC:2=D\C24:?8\E@\EC62E\E96>Qmk6>m%9:D DE@CJk^6>mk^2m k6>mH2D AC@5F465 3Jk^6>m k2 9C67lQ9EEADi^^<:G@]:@Qmk6>mz:G@k^6>mk^2m k6>m2?5 C6G:6H65 2?5 5:DEC:3FE65 3Jk^6>m k2 9C67lQ9EEADi^^9F3D]=2^"_b<=8$#_Q C6=lQ?@7@==@HQmk6>m$E24<6Ck^6>mk^2m]k^Am
