RESEARCH TRIANGLE PARK, N.C., May 22, 2025 /PRNewswire/ -- Bantam Pharmaceutical, a drug discovery and development company targeting selective modulation of mitochondrial dynamics in cancer, today announced that its Trial in Progress abstract has been accepted for presentation at the American Society of Clinical Oncology (ASCO) 2025 Annual Meeting, which is being held May 30 – June 3, 2025 at the McCormick Place Convention Center in Chicago, Illinois. The poster will highlight the company's ongoing Phase 1 trial evaluating its lead product candidate, BTM-3566, in patients with relapsed/refractory mature B-cell lymphomas. BTM-3566 is a first-in-class, small molecule cancer therapeutic which targets difficult-to-treat, aggressive tumors by activating OMA1-ATF4 Integrated Stress Response (ISR), a newly described mitochondrial homeostasis pathway.
kAm%96 !92D6 ` >F=E:46?E6C[ AC@DA64E:G6[ 5@D6\6D42=2E:@? DEF5J :D 7@4FD65 @? 6?C@==:?8 A2E:6?ED :? kDA2? 4=2DDlQI?\=@42E:@?QmE96 &?:E65 $E2E6Dk^DA2?m 2?5 kDA2? 4=2DDlQI?\=@42E:@?Qmr2?252k^DA2?m[ H:E9 E96 7:CDE &]$] D:E6 24E:G2E65 2E %96 kDA2? 4=2DDlQI?\@C8Qm&?:G6CD:EJ @7 %6I2Dk^DA2?m |s p?56CD@? r2?46C r6?E6C]k^Am
kAmQ!2E:6?ED H:E9 C6=2AD65 @C C67C24E@CJ q\46== =J>A9@>2D 4@?E:?F6 E@ 7246 D:8?:7:42?E 4=:?:42= 492==6?86D[ A2CE:4F=2C=J E9@D6 H9@ 92G6 AC@8C6DD65 7@==@H:?8 46== E96C2AJ @C E2C86E65 286?ED[Q D2:5 sC] kDA2? 4=2DDlQI?\A6CD@?Qm|:4926= (2?8k^DA2?m[ 8=@32= AC:?4:A2= :?G6DE:82E@C 2?5 AC@76DD@C @7 =J>A9@>2 U2>Aj >J6=@>2 2E %96 kDA2? 4=2DDlQI?\@C8Qm&?:G6CD:EJ @7 %6I2Dk^DA2?m |s p?56CD@? r2?46C r6?E6C] Q%96 @AA@CEF?:EJ E@ :?G6DE:82E6 q%|\bdee 2?5 :ED ?@G6= >6492?:D> @7 24E:@? :D 6DA64:2==J 4@>A6==:?8 8:G6? :ED AC64=:?:42= 24E:G:EJ 24C@DD 5:G6CD6 96>2E@=@8:4 EF>@C >@56=D[ :?4=F5:?8 E9@D6 H:E9 9:89\C:D< 762EFC6D] p5G2?4:?8 q%|\bdee :?E@ E96 4=:?:4 C6AC6D6?ED 2? :>A@CE2?E DE6A E@H2C5 6IA2?5:?8 E96C2A6FE:4 @AE:@?D 7@C A2E:6?ED H9@ FC86?E=J ?665 >@C6 67764E:G6 EC62E>6?ED]Qk^Am
kAmx? E96 &]$][ E96 DEF5J 7@==@HD 2 DE2?52C5 bZb 5@D6 6D42=2E:@? 56D:8? 368:??:?8 2E _]b >8^<8[ H9:=6 E96 r2?25:2? DF3\AC@E@4@= :?:E:2E6D 2E _]h >8^<8 FD:?8 2 D:?8=6\A2E:6?E 4@9@CE H:E9 2446=6C2E65 5@D6 E:EC2E:@?] x? 3@E9 C68:@?D[ A2E:6?ED C646:G6 q%|\bdee @C2==J @? s2JD ` E9C@F89 f @7 2 `c\52J 4J4=6] %96 4@>A=6>6?E2CJ\5F2=\4@F?ECJ 2AAC@249 2446=6C2E6D E96 :56?E:7:42E:@? @7 4=:?:42==J 24E:G6 5@D6D 7@C =J>A9@>2 A2E:6?ED H9:=6 AC6D6CG:?8 E96 D4:6?E:7:4 C:8@C C6BF:C65 E@ 6?DFC6 >62?:?87F= 4=:?:42= :>A24E] xE :D 6IA64E65 E@ DFAA@CE 7FEFC6 92C>@?:K2E:@? @7 &]$] 2?5 r2?25:2? 52E2 E@ 86?6C2E6 2 C@3FDE[ :?E68C2E65 52E2D6E 2?5 :?7@C> 56G6=@A>6?E DEC2E68J]k^Am
kAm!C:>2CJ 6?5A@:?ED 2C6 D276EJ 2?5 E@=6C23:=:EJ] $64@?52CJ 2?5 6IA=@C2E@CJ 6?5A@:?ED :?4=F56 @3;64E:G6 C6DA@?D6 C2E6 W~##X 3J C6G:D65 {F82?@ 4C:E6C:2[ 5FC2E:@? @7 C6DA@?D6 Ws@#X[ AC@8C6DD:@?\7C66 DFCG:G2= W!u$X[ 2?5 A92C>24@<:?6E:4 2?5 A92C>24@5J?2>:4 2DD6DD>6?ED] x?:E:2= 4=:?:42= 52E2 7C@> E96 EC:2= 2C6 6IA64E65 :? E96 D64@?5 92=7 @7 a_ad]k^Am
kAm(9:=6 E96 4FCC6?E EC:2= :D 7@4FD65 @? EC62E:?8 =J>A9@>2D E9C@F89 24E:G2E:?8 E96 ~|p`\p%uc x$#[ E96 >6492?:D> C6AC6D6?ED 2 3C@256C E96C2A6FE:4 @AA@CEF?:EJ] #646?E AC64=:?:42= 7:?5:?8D 92G6 D9@H? E92E q%|\bdee 5C:G6D D:8?:7:42?E C68C6DD:@?D :? 3:@>2C<6C\D6=64E65 D@=:5 EF>@CD – A2CE:4F=2C=J :? 5:77:4F=E\E@\EC62E EF>@C EJA6D] p55:E:@?2==J[ 4@>3:?2E:@? 52E2 56>@?DEC2E6 DJ?6C8J H:E9 DE2?52C5\@7\42C6 286?ED :? 24FE6 >J6=@:5 =6F<6>:2[ F?56CD4@C:?8 E96 3C@25 A@E6?E:2= @7 E9:D >6492?:D> 24C@DD 3@E9 96>2E@=@8:42= 2?5 D@=:5 EF>@CD] %96 4@>A2?J :?E6?5D E@ 25G2?46 E96D6 7:?5:?8D 4=:?:42==J 2D AC@5F4E 56G6=@A>6?E AC@8C6DD6D]k^Am
kAmkDEC@?8m!@DE6C !C6D6?E2E:@? s6E2:=Dk^DEC@?8mk^Am
kAm%:E=6i p A92D6 ` EC:2= @7 q%|\bdee :? C6=2AD65^C67C24E@CJ >2EFC6 q 46== =J>A9@>2Dk^Am
kAm!C6D6?E6Ci kDA2? 4=2DDlQI?\A6CD@?Qm|:4926= (2?8k^DA2?m[ |s[ s6A2CE>6?E @7 {J>A9@>2 U2>Aj |J6=@>2[ |s p?56CD@? r2?46C r6?E6Ck^Am
kAm$6DD:@?i w6>2E@=@8:4 |2=:8?2?4:6D—{J>A9@>2 2?5 r9C@?:4 {J>A9@4JE:4 {6F<6>:2k^Am
kAms2E6^%:>6i kDA2? 4=2DDlQI?\49C@?Qm$F?52J[ yF?6 `k^DA2?mkDFAmDEk^DFAm 2E kDA2? 4=2DDlQI?\49C@?Qm`_ 2]>] E@ ` A]>] t%k^DA2?mk^Am
kAmp3DEC24E }F>36Ci %!$f_hfk^Am
kAmp55:E:@?2= >66E:?8 :?7@C>2E:@? 42? 36 7@F?5 @? E96 p$r~ H63D:E6[ k2 9C67lQ9EEADi^^4a`a]?6E^4^=:?<^nEl_U2>Aj=l6?U2>Aj@lccbbfcg\`U2>Aj9lafgfafeaddU2>AjFl9EEADTbpTauTau2D4@]@C8TauU2>Aj2l9EEADTbpTauTau2D4@]@C8Q C6=lQ?@7@==@HQ E2C86ElQ03=2?<Qm9EEADi^^2D4@]@C8k^2m] %96 A@DE6C AC6D6?E2E:@? H:== 36 >256 2G2:=23=6 F?56C E96 k2 9C67lQ9EEADi^^4a`a]?6E^4^=:?<^nEl_U2>Aj=l6?U2>Aj@lccbbfcg\`U2>Aj9lah``aabgchU2>AjFl9EEADTbpTauTau32?E2>A92C>2]4@>Tau?6HD\C6D@FC46DTauU2>Aj2l}6HDZTaeZ#6D@FC46DQ C6=lQ?@7@==@HQ E2C86ElQ03=2?<Qm}6HD U2>Aj #6D@FC46Dk^2m D64E:@? @7 E96 4@>A2?JVD H63D:E6 D9@CE=J 27E6C E96 6G6?E]k^Am
kAmkDEC@?8mp3@FE q%|\bdeek^DEC@?8mk^Am
kAmq%|\bdee :D 2 ?@G6=[ @C2==J 2G2:=23=6 D>2== >@=64F=6 56D:8?65 E@ E2C86E 2 H:56 C2?86 @7 42?46CD[ :?4=F5:?8 3@E9 96>2E@=@8:4 2?5 D@=:5 EF>@CD] xED :?:E:2= 4=:?:42= 7@4FD :D @? >2EFC6 q\46== =J>A9@>2D[ DF49 2D >2?E=6 46== =J>A9@>2 W|r{X[ 5:77FD6 =2C86 q\46== =J>A9@>2 Ws{qr{X[ qFC<:EEVD =J>A9@>2[ 2?5 7@==:4F=2C =J>A9@>2 Wu{X] x? AC64=:?:42= DEF5:6D[ q%|\bdee 56>@?DEC2E65 A@E6?E 2?E:\42?46C 24E:G:EJ[ 5C:G:?8 D:8?:7:42?E EF>@C C68C6DD:@? – 2?5 :? >2?J 42D6D[ 4@>A=6E6 EF>@C 6=:>:?2E:@? – :? >@56=D C6D:DE2?E E@ DE2?52C5 EC62E>6?ED[ :?4=F5:?8 rp#\% 46== E96C2AJ] q%|\bdee H@C<D 3J 5:DCFAE:?8 E96 >:E@49@?5C:2= 7F?4E:@? :? EF>@C 46==D[ EC:886C:?8 E96:C ?2EFC2= 46== 562E9 AC@46DD W2A@AE@D:DX] }@E23=J[ :ED 2?E:\EF>@C 24E:G:EJ :D :?56A6?56?E @7 EF>@C 86?@EJA6[ 255C6DD:?8 2 4C:E:42= ?665 7@C E96C2A:6D 42A23=6 @7 56=:G6C:?8 C@3FDE 2?5 5FC23=6 C6DA@?D6D 24C@DD 86?6E:42==J 5:G6CD6 42?46CD] (:E9 :ED F?:BF6 >6492?:D> @7 24E:@? 2?5 DEC@?8 AC64=:?:42= 52E2[ q2?E2> 2=D@ A=2?D E@ 6IA2?5 4=:?:42= 56G6=@A>6?E[ 3C@256?:?8 :ED A@E6?E:2= :>A24E 7@C A2E:6?ED H:E9 =:>:E65 EC62E>6?E @AE:@?D]k^Am
kAmrFCC6?E=J[ q2?E2> :D 4@?5F4E:?8 @?8@:?8 !92D6 ` 4=:?:42= EC:2=D :? 3@E9 E96 &]$] 2?5 kDA2? 4=2DDlQI?\=@42E:@?Qmr2?252k^DA2?m 6G2=F2E:?8 q%|\bdee :? C6=2AD65^C67C24E@CJ >2EFC6 q\46== =J>A9@>2D] u@C >@C6 :?7@C>2E:@? 23@FE E96 &]$] EC:2=[ G:D:E k2 9C67lQ9EEADi^^4a`a]?6E^4^=:?<^nEl_U2>Aj=l6?U2>Aj@lccbbfcg\`U2>Aj9lgedahbb__U2>AjFl9EEADTbpTauTau4=:?:42=EC:2=D]8@GTauU2>Aj2lr=:?:42=%C:2=D]8@GQ C6=lQ?@7@==@HQ E2C86ElQ03=2?<Qmr=:?:42=%C:2=D]8@Gk^2m 2?5 D62C49 }r%_efhafbc]Â u@C >@C6 :?7@C>2E:@? 23@FE E96 r2?25:2? EC:2=[ G:D:E k2 9C67lQ9EEADi^^4a`a]?6E^4^=:?<^nEl_U2>Aj=l6?U2>Aj@lccbbfcg\`U2>Aj9laehbh_gaghU2>AjFl9EEADTbpTauTauHHH]:DC4E?]4@>TauU2>Aj2lx$#r%}]4@>Q C6=lQ?@7@==@HQ E2C86ElQ03=2?<Qmx$#r%}]4@>k^2m 2?5 D62C49 x$#r%}`dcbghfh]k^Am
kAmkDEC@?8mp3@FE q2?E2> !92C>246FE:42=k^DEC@?8mk^Am
kAmq2?E2> !92C>246FE:42= :D 2 5CF8 5:D4@G6CJ 2?5 56G6=@A>6?E 4@>A2?J =6G6C28:?8 E96 A@H6C @7 >:E@49@?5C:2= 5J?2>:4D E@ 255C6DD 4C:E:42= F?>6E ?665D :? @?4@=@8J] &D:?8 :ED F?:BF6 6IA6CE:D6 :? >:E@49@?5C:2= 46==F=2C 3:@=@8J[ q2?E2> :D 25G2?4:?8 ?@G6=[ 7:CDE\:?\4=2DD @C2= D>2== >@=64F=6 E96C2A6FE:4D 7@C 5:77:4F=E\E@\EC62E 96>2E@=@8:42= 2?5 D@=:5 EF>@CD] %96 4@>A2?J 4FCC6?E=J 9@=5D 2? 24E:G6 x?G6DE:82E:@?2= }6H sCF8 Wx}sX 2AA=:42E:@? :? E96 &]$] 2?5 2 r=:?:42= %C:2= pAA=:42E:@? Wr%pX :? kDA2? 4=2DDlQI?\=@42E:@?Qmr2?252k^DA2?m 7@C :ED =625 42?5:52E6[ q%|\bdee[ E2C86E:?8 q\46== >2=:8?2?4:6D[ H:E9 A=2?D E@ 6IA2?5 4=:?:42= 56G6=@A>6?E :?E@ D@=:5 EF>@CD] {62C? >@C6 2E k2 9C67lQ9EEADi^^4a`a]?6E^4^=:?<^nEl_U2>Aj=l6?U2>Aj@lccbbfcg\`U2>Aj9lceeaacecdU2>AjFl9EEADTbpTauTau32?E2>A92C>2]4@>TauU2>Aj2l9EEADTbpTauTau32?E2>A92C>2]4@>TauQ C6=lQ?@7@==@HQ E2C86ElQ03=2?<Qm9EEADi^^32?E2>A92C>2]4@>^k^2m]k^Am
kAmkDEC@?8m|65:2 r@?E24EÂ k^DEC@?8mk^Am
kAmkDA2? 4=2DDlQI?\A6CD@?Qmy6??:76C p=>@?5k^DA2?mk^Am
kAmr@CA@C2E6 r@>>F?:42E:@?D Â k^Am
kAmq2?E2> !92C>246FE:42=k^Am
kAmk2 9C67lQ>2:=E@i;2=>@?5o32?E2>A92C>2]4@>Q C6=lQ?@7@==@HQ E2C86ElQ03=2?<Qm;2=>@?5o32?E2>A92C>2]4@>k^2m  k^Am
kAmk2 9C67lQ9EEADi^^4a`a]?6E^4^=:?<^nEl_U2>Aj=l6?U2>Aj@lccbbfcg\`U2>Aj9l`g_bh`edeU2>AjFl9EEATbpTauTauHHH]32?E2>A92C>2]4@>TauU2>Aj2lHHH]32?E2>A92C>2]4@>Q C6=lQ?@7@==@HQ E2C86ElQ03=2?<QmHHH]32?E2>A92C>2]4@>k^2mk^Am
kA :5lQ!&#{Qmk:>8 2=ElQr:D:@?Q 96:89ElQ`aQ DC4lQ9EEADi^^4a`a]?6E^4^:>8^72G:4@?]A?8nD?l}*hcae`U2>AjD5la_ad\_d\aaQ E:E=6lQr:D:@?Q H:5E9lQ`aQ ^m ':6H @C:8:?2= 4@?E6?E E@ 5@H?=@25 >F=E:>65:2ik2 9C67lQ9EEADi^^HHH]AC?6HDH:C6]4@>^?6HD\C6=62D6D^32?E2>\A92C>246FE:42=\E@\AC6D6?E\2E\E96\2>6C:42?\D@4:6EJ\@7\4=:?:42=\@?4@=@8J\2D4@\a_ad\2??F2=\>66E:?8\b_acebffb]9E>=Q :5lQ!#}&#{Q C6=lQ?@7@==@HQ E2C86ElQ03=2?<Qm9EEADi^^HHH]AC?6HDH:C6]4@>^?6HD\C6=62D6D^32?E2>\A92C>246FE:42=\E@\AC6D6?E\2E\E96\2>6C:42?\D@4:6EJ\@7\4=:?:42=\@?4@=@8J\2D4@\a_ad\2??F2=\>66E:?8\b_acebffb]9E>=k^2mk^Am
kAm$~&#rt q2?E2> !92C>246FE:42=[ {{rk^Am
kAmk:>8 DC4lQ9EEADi^^CE]AC?6HDH:C6]4@>^CE]8:7n}6HDxE6>x5l}*hcae`U2>Aj%C2?D>:DD:@?0x5la_ad_daa`g__!#0}t($0&$!#00000}*hcae`U2>Ajs2E6x5la_ad_daaQ DEJ=6lQ3@C56Ci_AIj H:5E9i`AIj 96:89Ei`AIjQ ^mk^Am
