Stem cell therapy for cerebral palsy moves closer to US trials

kAmr6C63C2= A2=DJ 27764ED C@F89=J k2 9C67lQ9EEADi^^2C49:G6]454]8@G^HHH045408@G^?43555^4A^52E2]9E>=Qm` :? bcd 49:=5C6?k^2m :? E96 &?:E65 $E2E6D] p3@FE k2 9C67lQ9EEADi^^HHH]46C63C2=A2=DJ]@C8^23@FE\46C63C2=\A2=DJ^AC6G2=6?46\2?5\:?4:56?46Qmfec[___ 49:=5C6? 2?5 25F=EDk^2m =:G6 H:E9 E96 4@?5:E:@?] $E2?52C5 EC62E>6?E 7@4FD6D @? >2?28:?8 DJ>AE@>D E9C@F89 A9JD:42= E96C2AJ[ >65:42E:@?D[ 2?5 2DD:DE:G6 56G:46D] }@?6 @7 E96D6 EC62E>6?ED C6A2:CD E96 3C2:? :?;FCJ 2E E96 C@@E @7 E96 4@?5:E:@?]k^Am

kAmu@C 72>:=:6D[ E9:D 92D >62?E 2 =@?8 H2:E 7@C D@>6E9:?8 36EE6C] x? u63CF2CJ a_ae[ 2 56G6=@A>6?E @FE @7 y2A2? @776C65 2 C62D@? E@ A2J 2EE6?E:@?[ k2 9C67lQ9EEADi^^HHH]46C63C2=A2=DJ46?E6C]4@>^Qmr6C63C2= !2=DJ r6?E6Ck^2m C6A@CED]k^Am

k9bmq23J %66E9 2D 2 $@FC46 @7 qC2:?\#6A2:C:?8 $E6> r6==Dk^9bm

kAmw6C6VD H96C6 E96 D4:6?46 86ED :?E6C6DE:?8] |@DE A6@A=6 2DD@4:2E6 DE6> 46== E96C2AJ H:E9 3@?6 >2CC@H @C F>3:=:42= 4@C5 3=@@5] k2 9C67lQ9EEADi^^HHH]<:5DH6==3:@]4@>^6?^Qmz:5DH6== q:@k^2m E@@< 2 5:776C6?E C@FE6 6?E:C6=J] %96:C A=2E7@C> FD6D $wts 46==D[ H9:49 DE2?5D 7@C DE6> 46==D 7C@> 9F>2? 6I7@=:2E65 564:5F@FD E66E9] x? A=2:? t?8=:D9i $E6> 46==D AF==65 7C@> E96 323J E66E9 J@FC <:5 =62G6D F?56C E96 A:==@H]k^Am

kAm$wts 46==D 36=@?8 E@ 2 42E68@CJ 42==65 >6D6?49J>2= DE6> 46==D[ 2?5 k2 9C67lQ9EEADi^^=:?<]DAC:?86C]4@>^2CE:4=6^`_]``ge^D`bagf\_ad\_cgag\JQmAC64=:?:42= C6D62C49k^2m 92D D9@H? E96J 42? C65F46 :?7=2>>2E:@?[ DFAA@CE 3=@@5 G6DD6= 8C@HE9[ 2?5 96=A ?6FC2= 46==D DFCG:G6] %96 :562 :D?VE E92E E96D6 46==D C63F:=5 52>2865 3C2:? E:DDF6 7C@> D4C2E49] x?DE625[ E96J >2J 4C62E6 4@?5:E:@?D :? E96 3C2:? E92E 2C6 >@C6 72G@C23=6 7@C ?2EFC2= C64@G6CJ 2?5 ?6FC@A=2DE:4:EJ[ H9:49 :D E96 3C2:?VD 23:=:EJ E@ C6H:C6 :ED6=7 27E6C :?;FCJ]k^Am

kAmu@C 2 4@?5:E:@? =:<6 46C63C2= A2=DJ[ H96C6 E96 @C:8:?2= 3C2:? :?;FCJ EJA:42==J 92AA6?D 367@C6[ 5FC:?8[ @C D9@CE=J 27E6C 3:CE9[ E92E <:?5 @7 3:@=@8:42= DFAA@CE DJDE6> 4@F=5 36 2 82>6\492?86C] xEVD DE:== E96@C6E:42= 2E D42=6[ 3FE E96 62C=J\DE286 52E2 92D 366? 6?4@FC28:?8 6?@F89 E@ ;FDE:7J E96 ?6IE DE6Ai C68F=2E65 9F>2? EC:2=D @? &]$] D@:=]k^Am

k9bm(9J E96 &]$] |2EE6CD 7@C %9:D %96C2AJk^9bm

kAmz:5DH6== q:@ 5:5?VE 7@C> 2 &]$]\32D65 4@>A2?J ;FDE 7@C E96 AC6DE:86 @7 2? p>6C:42? 255C6DD] %96 &?:E65 $E2E6D @776CD D@>6E9:?8 E92EVD 92C5 E@ C6A=:42E6 6=D6H96C6i 2 4@>3:?2E:@? @7 C:8@C@FD usp @G6CD:89E[ H@C=5\4=2DD A65:2EC:4 ?6FC@=@8J 46?E6CD[ 2?5 4=:?:42= C6D62C49 :?7C2DECF4EFC6 3F:=E 7@C 6I24E=J E9:D <:?5 @7 H@C<]k^Am

kAmqJ 6DE23=:D9:?8 z:5DH6== &$p[ E96 4@>A2?J 42? H@C< 5:C64E=J H:E9 E96 usp E@ 56D:8? EC:2= AC@E@4@=D[ A2CE?6C H:E9 p>6C:42? C6D62C49 :?DE:EFE:@?D[ 2?5 C64CF:E A2E:6?ED E9C@F89 =68:E:>2E6[ C68F=2E65 492??6=D] %92E =2DE A2CE >2EE6CD >@C6 E92? J@F >:89E E9:?<] %96 DE6> 46== E96C2AJ DA246 92D 366? A=28F65 7@C J62CD 3J F?C68F=2E65 4=:?:4D D6==:?8 F?AC@G6? EC62E>6?ED E@ 56DA6C2E6 72>:=:6D] !FCDF:?8 E96 7@C>2= usp A2E9H2J :D 2 56=:36C2E6 >@G6 :? E96 @AA@D:E6 5:C64E:@?[ 2?5 :EVD @?6 E92E =6?5D 4C65:3:=:EJ E@ E96 6?E:C6 AC@8C2>]k^Am

kAmk2 9C67lQ9EEADi^^HHH]E96A92C>2?2G:82E@C]4@>^?6HD^4@>A2?J\=2F?496D\E@\2446=6C2E6\56G6=@A>6?E\@7\2\?@G6=\48E\7@C\A65:2EC:4\4AQm%C669:== !2CE?6CDk^2m AC@G:565 E96 DEC2E68:4 :?G6DE>6?E 324<:?8 E@ >2<6 E9:D A@DD:3=6] %96 7:?2?4:2= 4@>>:E>6?E DF886DED E92E 3@E9 4@>A2?:6D D66 2 C62=:DE:4 A2E9 E@ 4@>>6C4:2=:K2E:@?[ ?@E ;FDE 2 C6D62C49 6IA6C:>6?E]k^Am

k9bm(92E E96 %:>6=:?6 p4EF2==J {@@<D {:<6k^9bm

kAm{6EVD 36 9@?6DE 23@FE H92E E9:D 2??@F?46>6?E 5@6D 2?5 5@6D?VE >62?] xE 5@6D?VE >62? 2 DE6> 46== EC62E>6?E 7@C 46C63C2= A2=DJ :D 2C@F?5 E96 4@C?6C] (92E :E 5@6D >62? :D E92E E96 8C@F?5H@C< :D 36:?8 =2:5 7@C 2 DECF4EFC65[ >F=E:\J62C AC@46DD E92E 4@F=5 6G6?EF2==J =625 E@ usp 2AAC@G2=]k^Am

kAm%92E AC@46DD :?4=F56D usp C6G:6H 2?5 2FE9@C:K2E:@? E@ 368:? 4=:?:42= EC:2=D[ !92D6 ` D276EJ DEF5:6D E@ 4@?7:C> E96 E96C2AJ 5@6D?VE 42FD6 92C>[ =2C86C 677:424J EC:2=D E@ >62DFC6 H96E96C :E 24EF2==J H@C<D[ 2?5 E96? 2 7F== C68F=2E@CJ 6G2=F2E:@? 367@C6 2?J 4@>>6C4:2= 2G2:=23:=:EJ]k^Am

kAmz:5DH6==VD =625 AC@8C2>[ 42==65 $"\$wts[ 92D 2=C625J AC@8C6DD65 E9C@F89 56G6=@A>6?E A92D6D @G6CD62D[ H:E9 62C=J 52E2 A@:?E:?8 E@ A@E6?E:2= >@E@C 7F?4E:@? :>AC@G6>6?ED :? 46CE2:? A65:2EC:4 A@AF=2E:@?D] qFE Q62C=J 52E2Q 2?5 Qusp\2AAC@G65 EC62E>6?EQ 2C6 D6A2C2E65 3J J62CD @7 H@C<[ >:==:@?D @7 5@==2CD[ 2?5 2 =@E @7 D4CFE:?J] u2>:=:6D D9@F=5 E2<6 E96 ?6HD 2D 2 C62D@? 7@C 42FE:@FD @AE:>:D>[ ?@E 2D 2 4@F?E5@H? 4=@4<]k^Am

k9bm%96 q:886C !:4EFC6 7@C r6C63C2= !2=DJ %C62E>6?Ek^9bm

kAmz:5DH6== :D?VE @A6C2E:?8 :? 2 G24FF>] $6G6C2= &]$] 24256>:4 46?E6CD[ :?4=F5:?8 sF<6 &?:G6CD:EJ[ 92G6 2=C625J k2 9C67lQ9EEADi^^>65D49@@=]5F<6]65F^?6HD^F>3:=:42=\4@C5\3=@@5\:>AC@G6D\>@E@C\D<:==D\D@>6\49:=5C6?\46C63C2=\A2=DJQmAF3=:D965 C6D62C49 @? 4@C5 3=@@5 :?7FD:@?Dk^2m 7@C 49:=5C6? H:E9 46C63C2= A2=DJ[ C6A@CE:?8 D:8?D @7 >@E@C :>AC@G6>6?E :? D@>6 8C@FAD] ~E96C E62>D 2C6 DEF5J:?8 >6D6?49J>2= DE6> 46==D 7C@> 3@?6 >2CC@H 2?5 4@C5 E:DDF6]k^Am

kAm}@ DE6> 46== AC@5F4E 92D C646:G65 7F== usp 2AAC@G2= DA64:7:42==J 7@C 46C63C2= A2=DJ J6E] qFE E96 8C@H:?8 ?F>36C @7 C68F=2E65 EC:2=D E6==D J@F D@>6E9:?8 23@FE H96C6 E96 7:6=5 :D 962565] %96 4@?G6CD2E:@? :D D9:7E:?8 7C@> Q:7Q E@ QH96?Q 2?5 Q9@H H6==]Qk^Am

kAmu@C ?@H[ E96 >@DE 67764E:G6 46C63C2= A2=DJ EC62E>6?E DEC2E68J C6>2:?D H92E :EVD 366?i 62C=J :?E6CG6?E:@? E96C2AJ[ @CE9@A65:4 >@?:E@C:?8[ >65:42E:@? >2?286>6?E[ ?FEC:E:@?2= DFAA@CE[ 2?5 4@?D:DE6?E 56G6=@A>6?E2= 7@==@H\FA] #686?6C2E:G6 >65:4:?6 >2J 6G6?EF2==J 255 2?@E96C @AE:@? E@ E92E =:DE] p?5 H:E9 z:5DH6== &$p ?@H :? E96 A:4EFC6[ E96 A2E9 E@ 86EE:?8 E96C6 ;FDE 3642>6 2 3:E >@C6 4@?4C6E6]k^Am

k9bm|6E9@5@=@8Jk^9bm

kAm%9:D 2CE:4=6 :D 32D65 @? k2 9C67lQ9EEADi^^HHH]46C63C2=A2=DJ46?E6C]4@>^?6HD^<:5DH6==\=2F?496D\677@CE\E@\3C:?8\46C63C2=\A2=DJ\DE6>\46==\E96C2AJ\E@\FD^QmC6A@CE:?8 7C@> E96 r6C63C2= !2=DJ r6?E6Ck^2m[ :?5FDECJ 4@G6C286 7C@> %96 !92C>2 {6EE6C 2?5 r:E6=:?6 $4C:A[ 2?5 AF3=:4=J 2G2:=23=6 :?7@C>2E:@? 7C@> z:5DH6== q:@ C682C5:?8 :ED 46== E96C2AJ 56G6=@A>6?E AC@8C2>] q24<8C@F?5 52E2 @? 46C63C2= A2=DJ AC6G2=6?46 2?5 6I:DE:?8 EC62E>6?E >@52=:E:6D H6C6 82E96C65 E9C@F89 2 DFCG6J 4@?5F4E65 G:2 !@==7:D9 2?5 DFAA=6>6?E65 3J AF3=:D965 >65:42= =:E6C2EFC6] r=:?:42= EC:2= DE2EFD H2D 4C@DD\C676C6?465 H:E9 k2 9C67lQ9EEAi^^r=:?:42=%C:2=D]8@GQmr=:?:42=%C:2=D]8@Gk^2m C64@C5D 2D @7 u63CF2CJ a_ae]k^Am

kAmk2 9C67lQ9EEADi^^HHH]46C63C2=A2=DJ46?E6C]4@>^?6HD^<:5DH6==\=2F?496D\677@CE\E@\3C:?8\46C63C2=\A2=DJ\DE6>\46==\E96C2AJ\E@\FD^Qmk6>m%9:D DE@CJk^6>mk^2m k6>mH2D AC@5F465 3Jk^6>m k2 9C67lQ9EEADi^^HHH]46C63C2=A2=DJ46?E6C]4@>^Qmk6>mr6C63C2= !2=DJ r6?E6Ck^6>mk^2m k6>m2?5 C6G:6H65 2?5 5:DEC:3FE65 3Jk^6>m k2 9C67lQ9EEADi^^9F3D]=2^"_b<=8$#_Q C6=lQ?@7@==@HQmk6>m$E24<6Ck^6>mk^2m]k^Am