(Photo by Nicola Narracci via Pexels)
Sex chromosomes drive how human cells respond to disease — including cancer, reveals new research.
×
Javascript is required for you to be able to read premium content. Please enable it in your browser settings.
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 DEF5J 3C:?8D E@86E96C 8C@H:?8 6G:56?46 E92E E96 ) 2?5 * 49C@>@D@>6D 5@ >F49 >@C6 E92? ;FDE 56E6C>:?6 3:@=@8:42= D6I]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmxE D9@HD E92E E96J 5C:G6 E96 C:D< @7 D6G6C2= 5:D62D6D[ :?56A6?56?E @7 9@C>@?6D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 C6G:6H[ AF3=:D965 :? E96 ;@FC?2= k2 9C67lQ9EEADi^^HHH]D4:6?46]@C8^Qm$4:6?46k^2m[ C6G62=D E92E E96 ) 2?5 * 49C@>@D@>6D 2=D@ D92A6 9@H 46==D 7F?4E:@? 2?5 286]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmk2 9C67lQ9EEADi^^E2=<6C]?6HD^a_aa^_g^_b^DEF5J\4=2:>D\:ED\2\>JE9\E92E\H@>6?\>@C6\=:<6=J\E@\DFCG:G6\=@?86C\E92?\>6?^Qms:776C6?46D :? 962=E9 36EH66? >6? 2?5 H@>6?k^2m 92G6 =@?8 366? 2EEC:3FE65 >2:?=J E@ D6I 9@C>@?6D DF49 2D 6DEC@86? 2?5 E6DE@DE6C@?6]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmw@H6G6C[ >@C6 C646?E C6D62C49 DF886DED E92E 86?6D @? E96 ) 2?5 * 49C@>@D@>6D 2=D@ A=2J 2 5:C64E C@=6[ H@C<:?8 3@E9 @? E96:C @H? 2?5 2=@?8D:56 9@C>@?6D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 C6G:6H 56D4C:36D 9@H D6I 49C@>@D@>6D :?7=F6?46 :>>F?:EJ[ >6E23@=:D>[ 3C2:? 28:?8[ 42?46C 2?5 962CE 5:D62D6]k^Am
Dr. Dan Theodorescu is Nancy C. and Craig M. Berge Chair and Director of the University of Arizona Cancer Center. (University Arizona Cancer Center via SWNS)
By Talker
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm$EF5J 4@\=6256C sC] s2? %96@5@C6D4F D2:5i Q) 2?5 * 49C@>@D@>6D 2C6 @7E6? E9@F89E @7 2D D:>A=6 56E6C>:?2?ED 7@C 3:@=@8:42= D6I[ 3FE E96:C C@=6 :? 9F>2? 962=E9 :D >F49 =2C86C]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ~FC C6G:6H D9@HD E92E E96D6 49C@>@D@>6D 42CCJ 86?6E:4 :?DECF4E:@?D E92E D92A6 9@H @FC 46==D 286 2?5 9@H @FC 3@5:6D 5676?5 282:?DE >2;@C 5:D62D6D E9C@F89@FE @FC =:G6D]Qk^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 DEF5J C6G62=D E92E 86?6D @? E96 ) 2?5 * 49C@>@D@>6D[ C2E96C E92? 4:C4F=2E:?8 9@C>@?6 =6G6=D 2=@?6[ 56E6C>:?6 5:D62D6 C:D<[ AC@8C6DD:@? 2?5 E96C2A6FE:4 C6DA@?D6D 24C@DD <6J 962E9 2C62D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96D6 :?4=F56 28:?8[ 42?46C[ ?6FC@=@8:42= 4@?5:E:@?D[ :>>F?6 DJDE6> 7F?4E:@?D 2?5 42C5:@>6E23@=:4 5:D62D6]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 C6G:6H[ H9:49 6G2=F2E65 2?5 DJ?E96D:K65 6I:DE:?8 6G:56?46 7C@> 9F>2? DEF5:6D[ >@FD6 >@56=D 2?5 86?@>:4 E649?@=@8:6D[ 56D4C:36D D6G6C2= AC@46DD6D :?D:56 46==D E92E D92A6 962=E9 24C@DD E96 =:76DA2?]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmx? H@>6?[ @?6 @7 E96 EH@ ) 49C@>@D@>6D :D =2C86=J DH:E4965 @77 62C=J :? 56G6=@A>6?E[ 3FE D@>6 @7 :ED 86?6D DE2J 24E:G6 2?5 @E96CD 42? DH:E49 324< @? H:E9 286[ 8:G:?8 76>2=6 46==D 6IEC2 5@D6D @7 46CE2:? 86?6D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm$EF5:6D :? >:46 DF886DE :E 2=D@ >2EE6CD H96E96C 2 46==VD 24E:G6 ) 42>6 7C@> E96 >@E96C @C E96 72E96C]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm|6? :?96C:E E96:C @?=J ) 49C@>@D@>6 7C@> E96:C >@E96C[ H9:=6 :? H@>6? 6249 46== FD6D 6:E96C E96 >@E96CVD @C E96 72E96CVD 4@AJ]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmx? >:46 H9@D6 46==D C6=:65 >@DE=J @? E96 >@E96CVD )[ 72DE6C 3C2:? 28:?8 2?5 >6>@CJ 564=:?6 H6C6 @3D6CG65]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm(:E9 286[ D@>6 46==D =@D6 2 D6I 49C@>@D@>6] x? H@>6?[ =@DD @7 2? ) :D =:?<65 E@ 9:896C =6F<6>:2 C:D<[ 2=E9@F89 :ED 3C@256C 67764ED C6>2:? =2C86=J F?<?@H?]k^Am
Dr. Dan Theodorescu was the lead author of the study. (University Arizona Cancer Center via SWNS)
By Talker
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qmx? >6?[ =@DD @7 E96 *[ >@DE @7E6? >62DFC65 :? 3=@@5[ :D =:?<65 E@ 42?46CD[ 962CE 5:D62D6[ D6G6C6 :?764E:@?D 2?5 p=K96:>6CVD 5:D62D6]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96 =@DD @7 E9@D6 49C@>@D@>6D :D 36:?8 6IA=@C65 2D 3@E9 2 3:@>2C<6C @7 2?5 A@E6?E:2= 4@?EC:3FE@C E@ 286\C6=2E65 5:D62D6]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm&?:G6CD:EJ @7 pC:K@?2 A9JD:4:2?\D4:6?E:DE %96@5@C6D4F D2:5i Q(96? H6 =@@< :?D:56 9F>2? 46==D[ H6 D66 E92E ) 2?5 * 49C@>@D@>6D 2C6 A2CE:4:A2?ED :? 962=E9 2?5 5:D62D6 E9C@F89@FE 2 A6CD@?VD =:76]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQx? 42?46C[ 7@C 6I2>A=6[ @FC =23@C2E@CJ 92D 7@F?5 E92E EF>@CD E92E =@D6 E96 * 49C@>@D@>6 42? 6G256 E96 :>>F?6 DJDE6>[ J6E >2J C6DA@?5 36EE6C E@ k2 9C67lQ9EEADi^^E2=<6C]?6HD^a_ad^_f^_g^D4:6?E:DED\DF446DD7F==J\FD6\96CA6D\G:CFD\E@\EC62E\D<:?\42?46C^Qm:>>F?@E96C2AJk^2m]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ&?56CDE2?5:?8 E9:D 3:@=@8J 4@F=5 96=A FD E2:=@C EC62E>6?E]Qk^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96@5@C6D4FVD AC6G:@FD C6=2E65 C6D62C49 7@4FD65 @? 9@H E96 =@DD @7 E96 * 49C@>@D@>6 :? % 46==D 2?5 42?46C 46==D :? >6? 82G6 EF>@CD E96 23:=:EJ E@ k2 9C67lQ9EEADi^^E2=<6C]?6HD^a_a`^``^ac^42?46C\46==D\92G6\:?D64E\DEJ=6\4=2HD\E@\H2?56C\E@\@E96C\@C82?D^Qm6G256 E96 :>>F?6 DJDE6>k^2m[ AC@G:5:?8 2? 6IA=2?2E:@? H9J E96 =@DD @7 E96 49C@>@D@>6 92D 366? =:?<65 E@ :?4C62D65 >@CE2=:EJ 7C@> 42C4:?@>2D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm~E96C C646?E C6D62C49 3J 9:D 8C@FA D9@H65 9@H =@DD @7 E96 * 49C@>@D@>6 :? ?@C>2=\2AA62C:?8 E:DDF6D 24ED 2D 2? Q62C=J H2C?:?8 D:8?Q 2?5 >2J >2C< 2 9:556? K@?6 @7 86?6E:4 C:D< 7@C 42?46C E@ 56G6=@A]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9Qm%96@5@C6D4F 25565i Q~FC 9@A6 :D E92E E9:D C6G:6H H:== DE:>F=2E6 7FCE96C :?G6DE:82E:@? 2?5 3C:?8 8C62E6C 2H2C6?6DD E@ E96 D:8?:7:42?E A@E6?E:2= @7 DEF5J:?8 E96 ) 2?5 * 49C@>@D@>6D :? 42?46C 2?5 @E96C 5:D62D6D[ H:E9 72C\C6249:?8 5:28?@DE:4 2?5 E96C2A6FE:4 :>A=:42E:@?D]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ%9:D H@F=5 96=A 6?DFC6 E92E EC62E>6?ED 2?5 5:28?@DE:4D 2C6 E2:=@C65 E@ >2E49 6G6CJ A2E:6?EVD F?:BF6 AC@7:=6]k^Am
kA 4=2DDlQHA\3=@4<\A2C28C2A9QmQ(96? 4=:?:42= EC:2=D 2C6 56D:8?65 E@ 36 D6I\2H2C6[ C6D62C496CD 42? EFC? E96D6 46==F=2C 5:776C6?46D :?E@ A6CD@?2=:K65 >65:42= 42C6]Qk^Am
